Purpose To investigate the differences in brain glucose consumption
during olfactory stimulation between subjects affected
by multiple chemical sensitivity (MCS) and a group of
healthy individuals.
Methods Two 18F-FDG PET/CT scans were performed in 26
subjects (6 men and 20 women; mean age 46.7±11 years)
with a clinical diagnosis of MCS and in 11 healthy controls (6
women and 5 men; mean age 45.7±11 years), the first scan
after a neutral olfactory stimulation (NS) and the second after
a pure olfactory stimulation (OS). Differences in 18F-FDG
uptake were analysed by statistical parametric mapping
(SPM2).
Results In controls OS led to an increase in glucose consumption
in BA 18 and 19 and a reduction in glucosemetabolismin
BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase
in glucose consumption in BA 20, 23, 18 and 37 and a
reduction in glucose metabolism in BA 8, 9 and 10.
Conclusion The results of our study suggest that cortical
activity in subjects with MCS differs from that in healthy
individuals during olfactory stimulation.
Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study
Tipo Pubblicazione:
Articolo
Publisher:
Springer., Heidelberg;, Germania
Source:
European journal of nuclear medicine and molecular imaging (Print) 42 (2015): 733–740. doi:10.1007/s00259-014-2969-2
info:cnr-pdr/source/autori:Chiaravalloti A, Pagani M, Micarelli A, Di Pietro B, Genovesi G, Alessandrini M, Schillaci O/titolo:Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study/doi:10.1007/s00259-014-2
Date:
2015
Resource Identifier:
http://www.cnr.it/prodotto/i/324640
https://dx.doi.org/10.1007/s00259-014-2969-2
info:doi:10.1007/s00259-014-2969-2
Language:
Eng